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Modified silica nanoparticle coatings: Dual antifouling effects of self-assembled quaternary ammonium and zwitterionic silanes

硅烷 表面改性 生物污染 石英晶体微天平 吸附 硅烷 粘附 化学 蛋白质吸附 化学工程 硅醇 临界胶束浓度 纳米颗粒 高分子化学 材料科学 有机化学 纳米技术 胶束 水溶液 生物化学 物理化学 工程类 催化作用
作者
Brianna R. Knowles,Paweł Wagner,Shane Maclaughlin,Michael J. Higgins,Paul J. Molino
出处
期刊:Biointerphases [American Institute of Physics]
卷期号:15 (2) 被引量:7
标识
DOI:10.1116/1.5143141
摘要

This work examines the antifouling effect of quaternary ammonium silane (QAS) grafted from coatings of silica nanoparticles (SiNPs), independently and in combination with a zwitterionic sulfobetaine (SB) silane. The binding of QAS to the SiNP coatings was monitored using quartz crystal microgravimetry with dissipation monitoring (QCM-D) under varied pH and solution concentrations. Adsorption of bovine serum albumin protein was reduced on QAS modified SiNP coatings prepared under alkaline conditions due to the proposed generation of a pseudozwitterionic interface, where the underlying SiNP surface presents an anionic charge at high pH. Significant reductions in protein binding were achieved at low functionalization concentrations and short modification times. Additionally, SiNP coatings modified with a combination of QAS and SB chemistries were investigated. Surface modifications were performed sequentially, varying silane concentration and order of addition, and monitored using QCM-D. Dual-functionalized surfaces presented enhanced resistance to protein adsorption compared to QAS or SB modified surfaces alone, even at low functionalization concentrations. The antiadhesive and antibacterial properties of functionalized surfaces were investigated by challenging the surfaces against the bacterium Escherichia coli. All dual-functionalized coatings showed equal or reduced bacterial adhesion compared to QAS and SB functionalizations alone, while coatings functionalized with high concentrations of combined chemistries reduced the adhesion of bacteria by up to 95% compared to control SiNP surfaces.
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