清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Development of Predictive Nomograms for Clinical Use to Quantify the Risk of Amputation in Patients with Diabetic Foot Ulcer

列线图 医学 截肢 逻辑回归 单变量分析 糖尿病足 糖尿病足溃疡 接收机工作特性 糖尿病 风险因素 内科学 单变量 多元分析 外科 多元统计 统计 内分泌学 数学
作者
Bocheng Peng,Min Rui,Yiqin Liao,Aixi Yu
出处
期刊:Journal of diabetes research [Hindawi Publishing Corporation]
卷期号:2021: 1-9 被引量:27
标识
DOI:10.1155/2021/6621035
摘要

Objective. To determine the novel proposed nomogram model accuracy in the prediction of the lower-extremity amputations (LEA) risk in diabetic foot ulcer (DFU). Methods and Materials. In this retrospective study, data of 125 patients with diabetic foot ulcer who met the research criteria in Zhongnan Hospital of Wuhan University from January 2015 to December 2019 were collected by filling in the clinical investigation case report form. Firstly, univariate analysis was used to find the primary predictive factors of amputation in patients with diabetic foot ulcer. Secondly, single factor and multiple factor logistic regression analysis were employed to screen the independent influencing factors of amputation introducing the primary predictive factors selected from the univariate analysis. Thirdly, the independent influencing factors were applied to build a prediction model of amputation risk in patients with diabetic foot ulcer by using R4.3; then, the nomogram was established according to the selected variables visually. Finally, the performance of the prediction model was evaluated and verified by receiver working characteristic (ROC) curve, corrected calibration curve, and clinical decision curve. Results. 7 primary predictive factors were selected by univariate analysis from 21 variables, including the course of diabetes, peripheral angiopathy of diabetic (PAD), glycosylated hemoglobin A1c (HbA1c), white blood cells (WBC), albumin (ALB), blood uric acid (BUA), and fibrinogen (FIB); single factor logistic regression analysis showed that albumin was a protective factor for amputation in patients with diabetic foot ulcer, and the other six factors were risk factors. Multivariate logical regression analysis illustrated that only five factors (the course of diabetes, PAD, HbA1c, WBC, and FIB) were independent risk factors for amputation in patients with diabetic foot ulcer. According to the area under curve (AUC) of ROC was 0.876 and corrected calibration curve of the nomogram displayed good fitting ability, the model established by these 5 independent risk factors exhibited good ability to predict the risk of amputation. The decision analysis curve (DCA) indicated that the nomogram model was more practical and accurate when the risk threshold was between 6% and 91%. Conclusion. Our novel proposed nomogram showed that the course of diabetes, PAD, HbA1c, WBC, and FIB are the independent risk factors of amputation in patients with DFU. This prediction model was well developed and behaved a great accurate value for LEA so as to provide a useful tool for screening LEA risk and preventing DFU from developing into amputation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
creep2020完成签到,获得积分10
1秒前
2秒前
矛头蝮应助科研通管家采纳,获得10
3秒前
jh完成签到 ,获得积分10
23秒前
珂珂完成签到 ,获得积分10
43秒前
梦璃完成签到 ,获得积分10
49秒前
kenchilie完成签到 ,获得积分10
1分钟前
LeoBigman完成签到 ,获得积分10
1分钟前
北笙完成签到 ,获得积分0
1分钟前
任性的岱周完成签到,获得积分10
1分钟前
草拟大坝完成签到 ,获得积分0
1分钟前
路路完成签到 ,获得积分10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
2分钟前
AZN完成签到 ,获得积分10
2分钟前
123321完成签到 ,获得积分10
2分钟前
心无杂念完成签到 ,获得积分10
2分钟前
郭磊完成签到 ,获得积分10
2分钟前
图喵喵完成签到,获得积分10
2分钟前
通科研完成签到 ,获得积分10
2分钟前
YMM完成签到,获得积分10
3分钟前
CHEN完成签到 ,获得积分10
3分钟前
Ava应助老实的采蓝采纳,获得10
4分钟前
狼来了aas完成签到,获得积分10
4分钟前
4分钟前
4分钟前
gege完成签到,获得积分10
4分钟前
老实的采蓝完成签到,获得积分10
4分钟前
坚定修勾冲冲冲完成签到 ,获得积分10
4分钟前
辣小扬完成签到 ,获得积分10
4分钟前
房天川完成签到 ,获得积分10
4分钟前
4分钟前
Bethune124完成签到 ,获得积分10
5分钟前
淞淞于我完成签到 ,获得积分10
5分钟前
天天开心完成签到 ,获得积分10
5分钟前
Bethune完成签到 ,获得积分10
5分钟前
辣辣辣辣辣辣完成签到 ,获得积分10
6分钟前
科研通AI5应助科研通管家采纳,获得10
6分钟前
矛头蝮应助科研通管家采纳,获得10
6分钟前
6分钟前
高分求助中
(禁止应助)【重要!!请各位详细阅读】【科研通的精品贴汇总】 10000
Qualitative Inquiry and Research Design: Choosing Among Five Approaches 5th Edition 2000
International Code of Nomenclature for algae, fungi, and plants (Madrid Code) (Regnum Vegetabile) 1500
Linear and Nonlinear Functional Analysis with Applications, Second Edition 1200
Stereoelectronic Effects 1000
Robot-supported joining of reinforcement textiles with one-sided sewing heads 860
SPSS for Windows Step by Step: A Simple Study Guide and Reference, 17.0 Update (10th Edition) 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4197665
求助须知:如何正确求助?哪些是违规求助? 3733219
关于积分的说明 11755000
捐赠科研通 3406847
什么是DOI,文献DOI怎么找? 1869384
邀请新用户注册赠送积分活动 925306
科研通“疑难数据库(出版商)”最低求助积分说明 835827