靶向治疗
癌变
癌症研究
医学
癌症
药理学
免疫学
生物
内科学
作者
Giulia Petroni,Aitziber Buqué,Laurence Zitvogel,Guido Kroemer,Lorenzo Galluzzi
出处
期刊:Cancer Cell
[Elsevier]
日期:2021-03-01
卷期号:39 (3): 310-345
被引量:128
标识
DOI:10.1016/j.ccell.2020.11.009
摘要
At odds with conventional chemotherapeutics, targeted anticancer agents are designed to inhibit precise molecular alterations that support oncogenesis or tumor progression. Despite such an elevated degree of molecular specificity, many clinically employed and experimental targeted anticancer agents also mediate immunostimulatory or immunosuppressive effects that (at least in some settings) influence therapeutic efficacy. Here, we discuss the main immunomodulatory effects of targeted anticancer agents and explore potential avenues to harness them in support of superior clinical efficacy.
科研通智能强力驱动
Strongly Powered by AbleSci AI