γδT cell receptor ligands and modes of major histocompatibility complex I recognization

Backgroud T lymphocytes expressing the γδ-type of T cell receptors (TCR) for antigens contribute to all aspects of immune responses,including defenses against pathogene,tumors,allergy and autoimmunity,and major histocompatibility complex (MHC) Ⅰ molecules is one of major γδTCR ligands.Objective Multiple subsets have been individualized in humans as well as in mice and they appear to recognize in a TCR-dependent manner antigens implying diverse modes of antigen recognition.Reviewing the MHC Ⅰ molecules as one of major γδTCR ligands which is one way of discussing the possible character of γδTCR and γδT cells antigen recognition modes.Content The review introduces the character of γδT cells,then describes MHC Ⅰ molecules that can be recognized as ligands of γδTCR.Trend It is important that confirming the modes of γδT cells antigen recognition further more by the study of MHC Ⅰ molecules as specific ligands of γδ TCR. Key words: γδT-Cell;  Major histocompatibility complex Ⅰ ;  Ligand;  Antigen recognition