生物
麻疹病毒
病毒学
系统发育树
系统发育学
氨基酸
病毒
组织向性
受体
向性
遗传学
基因
副粘病毒科
病毒性疾病
作者
Ajay Yadav,Kaushal Kishor Rajak,Mukesh Bhatt,Ashok Kumar,Soumendu Chakravarti,M. Sankar,D. Muthuchelvan,Ravi Kumar,Sagar A. Khulape,Rabindra Prasad Singh,Raj Kumar Singh
出处
期刊:Canadian Journal of Microbiology
[Canadian Science Publishing]
日期:2019-11-01
卷期号:65 (11): 783-794
被引量:6
标识
DOI:10.1139/cjm-2019-0008
摘要
SLAM (CD150) and nectin-4 are the major morbillivirus receptors responsible for virus pathogenesis and host range expansion. Recently, morbillivirus infections have been reported in unnatural hosts, including endangered species, posing a threat to their conservation. To understand the host range expansion of morbilliviruses, we generated the full-length sequences of morbillivirus receptors (goat, sheep, and dog SLAM, and goat nectin-4) and tried to correlate their role in determining host tropism. A high level of amino acid identity was observed between the sequences of related species, and phylogenetic reconstruction showed that the receptor sequences of carnivores, marine mammals, and small ruminants grouped separately. Analysis of the ligand binding region (V region; amino acid residues 52–136) of SLAM revealed high amino acid identity between small ruminants and bovine SLAMs. Comparison of canine SLAM with ruminants and non-canids SLAM revealed appreciable changes, including charge alterations. Significant differences between feline SLAM and canine SLAM have been reported. The binding motifs of nectin-4 genes (FPAG motif and amino acid residues 60, 62, and 63) were found to be conserved in sheep, goat, and dog. The differences reported in the binding region may be responsible for the level of susceptibility or resistance of a species to a particular morbillivirus.
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