神经炎症
先天免疫系统
髓样
小胶质细胞
免疫系统
生物
转录组
细胞
巨噬细胞
神经科学
细胞生物学
免疫学
炎症
遗传学
体外
基因表达
基因
作者
Marta Joana Costa Jordão,Roman Sankowski,Stefanie M. Brendecke,Sagar Sagar,Giuseppe Locatelli,Yi-Heng Tai,Tuan Leng Tay,Eva Schramm,Stephan Armbruster,Nora Hagemeyer,Olaf Groß,Dominic Mai,Özgün Çiçek,Thorsten Falk,Martin Kerschensteiner,Dominic Grün,Marco Prinz
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2019-01-25
卷期号:363 (6425)
被引量:596
标识
DOI:10.1126/science.aat7554
摘要
The innate immune cell compartment is highly diverse in the healthy central nervous system (CNS), including parenchymal and non-parenchymal macrophages. However, this complexity is increased in inflammatory settings by the recruitment of circulating myeloid cells. It is unclear which disease-specific myeloid subsets exist and what their transcriptional profiles and dynamics during CNS pathology are. Combining deep single-cell transcriptome analysis, fate mapping, in vivo imaging, clonal analysis, and transgenic mouse lines, we comprehensively characterized unappreciated myeloid subsets in several CNS compartments during neuroinflammation. During inflammation, CNS macrophage subsets undergo self-renewal, and random proliferation shifts toward clonal expansion. Last, functional studies demonstrated that endogenous CNS tissue macrophages are redundant for antigen presentation. Our results highlight myeloid cell diversity and provide insights into the brain's innate immune system.
科研通智能强力驱动
Strongly Powered by AbleSci AI