急性肾损伤
医学
膦甲酸
阿扎那韦
英迪纳维
肾毒性
西多福韦
急性肾小管坏死
肾病
间质性肾炎
肾
药理学
更昔洛韦
内科学
免疫学
人类免疫缺陷病毒(HIV)
病毒载量
抗逆转录病毒疗法
病毒
糖尿病
人巨细胞病毒
内分泌学
出处
期刊:Infectious disorders drug targets
[Bentham Science]
日期:2019-12-23
卷期号:19 (4): 375-382
被引量:32
标识
DOI:10.2174/1871526519666190617154137
摘要
The introduction of more efficient antiviral drugs are common cause drug-induced acute kidney injury (AKI). The true prevalence of antiviral drugs induced nephrotoxicity is hardly determined. It causes AKI by many mechanisms including acute tubular necrosis (ATN), allergic interstitial nephritis (AIN), and crystal nephropathy. ATN has been described with a few kinds of antiviral drugs such as cidofovir, adefovir and tenofovir with unique effects on transporter defects, apoptosis, and mitochondrial injury. AIN from atazanavir is a rapid onset of AKI and usually nonoliguric but dialytic therapy are needed because of severity. Additionally, crystal nephropathy from acyclovir, indinavir, and foscarnet can cause AKI due to intratubular obstruction. In this article, the mechanisms of antiviral drug-induced AKI were reviewed and strategies for preventing AKI were mentioned.
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