Nanotopography: Nanotopography‐Induced Unfolding of Fibrinogen Modulates Leukocyte Binding and Activation (Adv. Funct. Mater. 14/2019)

In article number 1807453, Krasimir Vasilev and co-workers describe the role of surface nanotopography in modulating immune responses. By using model surfaces purposely engineered at the nanoscale, the team demonstrates nanotopography scale dependent fibrinogen unfolding, which leads to the exposure of normally hidden peptide sequences causing activation of the Mac-1 receptor of inflammatory cells.