High Pressure Tuning of Selectivity in Organic Synthesis.

Selectivity is an essential parameter in organic synthesis. Selectivity is influenced by physical, physicochemical, chemical parameters. If pressure is considered, the selectivity depends on the volume requirements of the variousreaction pathways when reaching the transition state. The paper reports on the effect of pressure on chemo-, regio-, stereo- and enantioselectivity in organic chemistry illustrated by prominent examples. As a general conclusion, highpressure is a useful parameter in controlling the selectivity.