Hox基因
细胞质
信号转导衔接蛋白
细胞生物学
泛素
泛素连接酶
生物
同源盒
泛素蛋白连接酶类
蛋白质亚单位
转录因子
核出口信号
蛋白磷酸酶1
核蛋白
核运输
磷酸酶
生物化学
细胞核
基因
磷酸化
作者
Noémie Deneyer,Laure Bridoux,Céline Bombled,Tamara Pringels,Isabelle Bergiers,Sébastien Pyr dit Ruys,Didier Vertommen,Jean-Claude Twizere,René Rezsohazy
标识
DOI:10.1016/j.bbagrm.2019.07.005
摘要
HOX proteins are homeodomain transcription factors critically involved in patterning animal embryos and controlling organogenesis. While the functions of HOX proteins and the processes under their control begin to be well documented, the modalities of HOX protein activity regulation remain poorly understood. Here we show that HOXA2 interacts with PPP1CB, a catalytic subunit of the Ser/Thr PP1 phosphatase complex. This interaction co-localizes in the cytoplasm with a previously described HOXA2 interactor, KPC2, which belongs to the KPC E3 ubiquitin ligase complex. We provide evidence that HOXA2, PPP1CB and KPC2 define a molecularly and functionally interacting complex. Collectively, our experiments support that PPP1CB and KPC2 together inhibit the activity of HOXA2 by activating its nuclear export, but favored HOXA2 de-ubiquitination and stabilization thereby establishing a store of HOXA2 in the cytoplasm.
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