适体
生物传感器
多样性(控制论)
计算机科学
过程(计算)
纳米技术
选择(遗传算法)
生化工程
工程类
材料科学
人工智能
生物
遗传学
操作系统
作者
Trevor A. Feagin,Nicolò Maganzini,H. Tom Soh
出处
期刊:ACS Sensors
[American Chemical Society]
日期:2018-08-29
卷期号:3 (9): 1611-1615
被引量:80
标识
DOI:10.1021/acssensors.8b00516
摘要
Aptamer biosensor that can switch its structure upon target binding offers a powerful strategy for molecular detection. However, the process of converting an aptamer into a "structure-switching" biosensor is challenging and often relies on trial-and-error without established design principles. In this Sensor Issues, we examine a variety of design approaches for incorporating structure-switching functionality into existing aptamers, and provide thermodynamic analyses to highlight the variables that most strongly influence their performance. Finally, we also describe emerging efforts for incorporating the structure-switching functionality directly into the aptamer selection process.
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