藤黄酸
化学
植物化学
蛋白质组
蛋白质组学
K562细胞
赫拉
生物化学
计算生物学
生物
细胞
体外
基因
作者
Yiqing Zhou,Weichao Li,Xixi Zhang,Haibing Zhang,Youli Xiao
摘要
Gambogic acid has shown significant potential as an anti-cancer and anti-inflammatory compound; however, the molecular mechanism underlying the actions of gambogic acid, particularly its cellular target profiles, has not been investigated. In this study, we report the proteome-wide profiling of potential cellular targets of gambogic acid using quantitative mass spectrometry-based chemical proteomics. The target profiles of gambogic acid in living HeLa and K562 cells were identified, which strengthened our understanding of the mode of actions of the phytochemical.
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