胶体金
管腔(解剖学)
生物医学工程
材料科学
膜
纳米技术
对比度(视觉)
体内
生物物理学
纳米颗粒
化学
细胞生物学
医学
生物
生物化学
计算机科学
生物技术
人工智能
作者
Santosh Aryal,Tuyen Duong Thanh Nguyen,Arunkumar Pitchaimani,Tej B. Shrestha,David S. Biller,Deryl L. Troyer
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2016-12-27
卷期号:3 (1): 36-41
被引量:26
标识
DOI:10.1021/acsbiomaterials.6b00573
摘要
Red blood cells (RBCs) are the natural resident of the vascular lumen, therefore delivery of any agents within the vascular lumen could benefit by unique natural transporting features of RBCs. RBCs continuously circulate for ∼100 days before being sequestered in the spleen, they only extravasate at sites of vascular hemorrhage. Taking advantages of these features, we engineered RBC as a carrier in order to design a unique delivery system capable of delivering X-ray computed tomography (CT) contrast agents, gold nanoparticles (AuNPs), thereby acting as CT-contrast agent. A strategic membrane fusion technique was used to engineer the surface of RBC with gold nanoparticles in this in vitro study without altering its shape, size, and surface properties.
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