Platelet-rich plasma in the therapy of osteoarthritis of temporomandibular joint

Background: Platelet-rich plasma (PRP) application uses the effect of changes in cell proliferation and regulation of cellular metabolism. In the temporomandibular joint (TMJ) is this effect desirable in treatment of osteoarthritis: regeneration of cartilage, bone and synovial tissue. Objectives: The presented study compares effect of intraarticular injection of PRP and hyaluronic acid in patients after ineffective previous conservative and mini-invasive treatment. The study includes 60 patients with arthroscopically proved degenerative changes of TMJ (grade I and II chondromalacia). Methods: All the 60 patients were randomly divided into two groups: group A received 1 mL PRP intraarticular and group B received 1 mL of hyaluronic acid (standard group). At the point of 1, 3 and 6 months after procedure the pain score and maximum interincisal opening were evaluated. Findings and Conclusions: Study proved PRP application as an effective treatment method with significant pain level decrease.