In vitro antiproliferative activity of flavonols: Fisetin, quercetin and kaempferol and their cyclodextrin complexes

The aim of this study was to evaluate the in vitro antiproliferative capacity of the flavonols: fisetin, quercetin and kaempferol alone and incorporated in β-cyclodextrins, on A2780 (human ovarian carcinoma cells), MDA-MB-231 (human breast cancer cells) and SiHa (human cervix cancer cells). On the selected cell lines, among the tested compounds, fisetin was the most active in terms of antiproliferative activity. The most sensitive cell line to the tested flavonols was found to be the human ovarian carcinoma A2780 cell line. The inclusion complexes between the selected flavonols with ramified β-cyclodextrins determined different effects, depending on the cell line and on the tested compound. © 2015, Romanian Society for Pharmaceutical Sciences. All rights reserved.