医学
缺血
脑血流
氧化应激
冲程(发动机)
炎症
脑缺血
再灌注损伤
神经保护
血流
麻醉
药理学
神经科学
内科学
心理学
工程类
机械工程
作者
Mengxing Li,He-Yong Tang,Zhen Li,Wei Tang
出处
期刊:Neuroscience
[Elsevier]
日期:2022-12-01
卷期号:507: 112-124
被引量:10
标识
DOI:10.1016/j.neuroscience.2022.10.020
摘要
Cerebral ischemia–reperfusion injury (CI/RI) injury is a common feature of ischemic stroke which occurs when the blood supply is restored after a period of ischemia in the brain. Reduced blood-flow to the brain during CI/RI compromises neuronal cell health as a result of mitochondrial dysfunction, oxidative stress, cytokine production, inflammation and tissue damage. Reperfusion therapy during CI/RI can restore the blood flow to ischemic regions of brain which are not yet infarcted. The long-term goal of CI/RI therapy is to reduce stroke-related neuronal cell death, disability and mortality. A range of drug and interventional therapies have emerged that can alleviate CI/RI mediated oxidative stress, inflammation and apoptosis in the brain. Herein, we review recent studies on CI/RI interventions for which a mechanism of action has been described and the potential of these therapeutic modalities for future use in the clinic.
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