孤雌内酯
倍半萜内酯
抗癌药
化学
药理学
癌症治疗
药品
癌症
传统医学
倍半萜
医学
立体化学
生物化学
细胞凋亡
内科学
作者
Xingchen LIU,Xiaobing WANG
标识
DOI:10.1016/s1875-5364(22)60238-3
摘要
Parthenolide (PTL) is a sesquiterpene lactone derived from medicinal plant feverfew (Tanacetum parthenium). Recent studies have demonstrated that it has multiple pharmacological activities, especially in the treatment of various hematological and solid cancers. The superior anticancer activity of PTL suggests that it has the potential to be a first-line drug. However, due to the limited physical and chemical properties, as well as bioavailability, structural modification strategies are strongly recommended to improve the anticancer activity. This review describes representative PTL derivatives obtained by different modification strategies, which are reported to exert antiproliferative activities superior to the parent compound PTL. Furthermore, we also summarize their basic mechanisms on cancer-related signaling pathways, so as to explain the potential and characteristics of PTL and its derivatives in cancer therapy.
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