材料科学
生物相容性
抗菌剂
体内
纳米技术
伤口愈合
纳米材料
DNA
体外
细菌
自愈
生物相容性材料
微生物学
生物医学工程
生物
生物化学
免疫学
医学
生物技术
病理
冶金
替代医学
遗传学
作者
Shima Liu,Qinglong Yan,Shuting Cao,Lihua Wang,Shihua Luo,Min Lv
标识
DOI:10.1021/acsami.2c13805
摘要
Antimicrobial nanomaterials hold great promise for bacteria-infected wound healing. However, it remains a challenge to balance antimicrobial efficacy and biocompatibility for these artificial antimicrobials. Here we employed biocompatible genetic molecule DNA as a building material to fabricate antimicrobial materials, including self-assembled Y-shaped DNA-silver nanocluster composite (Y-Ag) and Y-Ag hydrogel (Y-Ag-gel). We demonstrate that macroscopic and microcosmic DNA-Ag composites can effectively inhibit bacterial growth but do not affect cell proliferation in vitro. In particular, Y-Ag spray can speed up the process of wound healing in vivo. Considering the efficacy and advantages of DNA-based materials, our findings provide a promising route to fabricate a novel wound dressing such as spray and hydrogel for therapeutic wound healing.
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