光热治疗
材料科学
伤口愈合
血管生成
细菌纤维素
纤维素
粘附
体内
细菌
微生物学
生物医学工程
纳米技术
化学
医学
复合材料
癌症研究
生物
生物化学
免疫学
生物技术
遗传学
作者
Yan Wu,Dong‐Xu Jia,Kunyan Lu,Haixin Zhang,Chunxia Liu,Yuancheng Lin,Jingjing Cheng,Yi Zou,Huibin Xu,Hong Chen,Yanxia Zhang,Qian Yu
标识
DOI:10.1016/j.jmst.2023.04.005
摘要
For most traditional wound dressings, it is challenging to simultaneously eliminate bacteria and promote angiogenesis to accelerate the healing process of bacteria-infected wounds. In this work, we develop a multifunctional dressing based on bacterial cellulose (BC) deposited with a tannic acid/Cu2+ ion/Mg2+ ion (TCM) complex film. Overall, the TCM complex exhibits robust interfacial adhesion to modify BC and good photothermal properties to effectively eradicate bacteria in the wound area under near-infrared (NIR) irradiation. The individual components of the TCM complex have several advantageous features for wound healing, such as antibacterial ability and negligible cytotoxicity; in particular, the released Cu2+ and Mg2+ ions are favorable for the proliferation, migration, and tube formation of endothelial cells in vitro. The results of in vivo experiments demonstrated that with the assistance of NIR irradiation, this composite dressing is more effective than traditional gauze or pristine BC dressing in promotion of angiogenesis and collagen deposition without causing remarkable inflammation, thereby accelerating the healing process of bacteria-infected full-thickness skin wounds. This work thus provides a simple and facile way to fabricate multifunctional BC-based dressings that could be potentially used for treating infected wounds.
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