The Effects of Lesion Network Guided Transcranial Electrical Stimulation on Symptoms and Electrophysiology in Psychosis

Transcranial electrical stimulation (tES) may improve symptoms and cognition in psychosis spectrum disorders. Few investigations use high definition tES (HD-tES) to more specifically target brain circuits. Convergent neuroimaging, neurophysiological, and cause-effect studies in psychosis point towards extrastriate cortex (V5/MT) alterations. We aim to determine if causal lesion network guided HD-tES to the extrastriate cortex is efficacious and safe in psychosis.