总苞素
角质形成细胞
洛里克林
丝状蛋白
细胞分化
精氨酸酶
生物
细胞生物学
免疫学
生物化学
精氨酸
体外
氨基酸
基因
特应性皮炎
作者
Denis Szondi,Rachel A Crompton,Linus Oon,Nagavidya Subramaniam,Khek‐Chian Tham,Sze Han Lee,Helen Williams,Joanne L. Pennock,Thiam Chye Lim,Carine Bonnard,Jason Wong,Leah A. Vardy,Sheena Cruickshank
摘要
ARG1 activity plays a major role in keratinocyte differentiation and AMP production. ARG1 is downregulated in an AD model, and in cell systems its function can be rescued by the ARG1 downstream products putrescine and urea. Manipulation of the ARG1 pathway may have the potential to be used for the management of skin conditions such as AD.
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(2025-6-4)
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