PURPOSE: The aim of this study was to identify predictors for self-efficacy level in patients with venous leg ulcer (VLU). DESIGN: Observational, cross-sectional, correlational study. SUBJECTS AND SETTING: The sample comprised 263 participants recruited from 4 tertiary grade A general hospitals (high acuity and technology) in Qingdao and Tianjin, China from February to December 2022. METHODS: Data collection was carried out by distributing a questionnaire that included the Venous Leg Ulcer Self-efficacy Tool, Medical Coping Modes Questionnaire, and Social Support Rating Scale to potential respondents. Independent sample t test, 1-way analysis of variance, Pearson correlation, and multiple linear regression were used for data analysis. RESULTS: Participants’ mean self-efficacy score was 210.50 (standard deviation: 48.15). Multiple linear regression indicated that social support (β = 0.359, P = .001) and confrontation coping mode (β = 0.258, P < .001) were the most significant predictors of self-efficacy in participants with VLUs. CONCLUSIONS: Study findings suggest that psychosocial interventions that strengthen social support and adopting confrontation coping mode may contribute to the improved self-efficacy in VLU patients.