Triglyceride‐Glucose Index Is Associated With Restenosis After Percutaneous Coronary Intervention With Drug‐Coated Balloons in Patients With Coronary Artery Disease

ABSTRACT Background Drug‐coated balloon (DCB) has become a common treatment, but restenosis may still occur after DCB. The association of the triglyceride‐glucose (TyG) index with coronary atherosclerotic heart disease prognosis has been demonstrated. However, the relationship between the TyG index and restenosis after DCB‐only remains unknown. Aims This study aimed to investigate the relationship between the TyG index and restenosis after DCB‐only. Methods The present study retrospectively recruited patients who underwent coronary angiography at 6−36 months after successful based DCB‐only percutaneous coronary intervention. Subgroup analyses, correlation analyses, and, most importantly, a multivariate logistic regression analysis model were also constructed to assess the association between TyG index and restenosis after DCB treatment. Results A total of 173 patients received DCB‐only therapy (58.22 ± 11.16 years of age, 74.6% male) were included in this study (mean follow‐up time of 13.0 ± 7.7 months). The TyG index was higher in the restenosis group than in the non‐restenosis group at both baseline (9.24 ± 0.73 vs. 8.65 ± 0.60, p < 0.001) and follow‐up (9.00 ± 0.77 vs. 8.54 ± 0.55, p < 0.001). The positive association between the TyG index and the restenosis after DCB was also determined in the fully adjusted model. The association was also reflected in all subgroups. Moreover, AUC of ROC showed that TyG index could provide predictive value for DCB‑Restenosisat baseline, both at baseline (AUC: 0.756, 95% CI 0.678 to 0.833, p < 0.001) and follow‐up (AUC: 0.679, 95% CI 0.594 to 0.765, p < 0.001). Conclusion An elevated TyG index was independently and positively correlated with the risk of restenosis in patients treated with DCB‐only. The TyG index obtained both at baseline and at follow‐up was predictive of restenosis after DCB, but the exact mechanism is unclear and requires further study.