Decoding neutrophil extracellular traps and key gene drivers in unexplained pregnancy loss

This study establishes a novel link between NETs and the pathogenesis of uRPL. It highlights the abnormal activation of C3AR1, ITGAM, ITGB2, and LYZ, along with M2 macrophage polarization, as crucial factors in decidual immune dysregulation. These findings suggest that NETs could serve as therapeutic targets, while DE-NRGs may act as potential biomarkers for uRPL.