医学
免疫组织化学
生物标志物
肺癌
病理
肺
肿瘤科
癌症
癌症研究
内科学
生物
生物化学
作者
Magdalena M. Brune,Luca Roma,Obinna Chijioke,Ilaria Alborelli,Martin Zacharias,Lenard Bubendorf,Tatjana Vlajnic,Nikolaus Deigendesch,Julian Pollinger,Petra Hirschmann,David König,Sebastian Ott,Spasenija Savic-Prince,Lukas Bubendorf
标识
DOI：10.1016/j.jtho.2025.08.014
摘要
MTAP IHC seems to be better suited than OPA-NGS to assess the MTAP status in NSCLC, especially as the MTAP gene is not specifically covered within this panel. CDKN2A loss is not a reliable MTAP loss surrogate, as it overestimates MTAP loss in more than 25% of the cases in the TCGA cohort.
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(2025-6-4)
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