生物活性玻璃
介孔材料
药物输送
材料科学
生物医学工程
钙
磷酸钙骨水泥
间质细胞
药品
化学
纳米技术
药理学
复合材料
医学
生物化学
癌症研究
冶金
催化作用
作者
Richard Frank Richter,Corina Vater,Margarete Korn,Tilman Ahlfeld,Martina Rauner,Winnie Pradel,Bernd Stadlinger,Michael Gelinsky,Anja Lode,Paula Korn
标识
DOI:10.1016/j.bioactmat.2023.06.001
摘要
Calcium phosphate cements (CPC) are currently widely used bone replacement materials with excellent bioactivity, but have considerable disadvantages like slow degradation. For critical-sized defects, however, an improved degradation is essential to match the tissue regeneration, especially in younger patients who are still growing. We demonstrate that a combination of CPC with mesoporous bioactive glass (MBG) particles led to an enhanced degradation in vitro and in a critical alveolar cleft defect in rats. Additionally, to support new bone formation the MBG was functionalized with hypoxia conditioned medium (HCM) derived from rat bone marrow stromal cells. HCM-functionalized scaffolds showed an improved cell proliferation and the highest formation of new bone volume. This highly flexible material system together with the drug delivery capacity is adaptable to patient specific needs and has great potential for clinical translation.
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