One-Pot Preparation of an Antioxidant, Anti-Inflammatory, and Analgesic Hydrogel for Oral Mucosal Lesions

< 0.05). Histopathological analysis revealed a 60.05% reduction in inflammatory cytokine infiltration and a 2.8-fold increase in collagen deposition. The dual-action therapeutic platform combined structural stability with bioactive functionality, creating a protective niche that modulated the wound microenvironment through via three synergistic mechanisms: (1) mechanical barrier formation, (2) oxidative stress mitigation (93.8% ROS scavenging capacity), and (3) prolonged analgesic efficacy. This rationally designed hydrogel system offered a clinically translatable solution for oral mucosal regeneration, addressing both biological healing requirements and patient comfort through its tunable physicochemical properties and controlled therapeutic delivery.