化学
芳基
催化作用
试剂
镍
卤化物
甘氨酸
氨基甲酸酯
电泳剂
有机化学
组合化学
氨基酸
烷基
生物化学
作者
Malcolm P. Huestis,Eun Seo Choi,Sophie Rousseaux
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2024-01-12
标识
DOI:10.1055/s-0043-1763656
摘要
Abstract A nickel-catalyzed aminomethylation of aryl or heteroaryl iodides or bromides for the preparation of protected primary benzylamines is reported. This cross-electrophile reductive protocol engages carbamate-protected, glycine-derived N-hydroxyphthalimide (NHP) esters in an efficient decarboxylative cross-coupling in only two hours. The catalyst and NHP ester reagents are commercially available or can be synthesized in one step on a decagram scale with no chromatography.
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