鼻咽癌
癌症研究
PI3K/AKT/mTOR通路
蛋白激酶B
体内
发病机制
表皮生长因子受体
信号转导
生物
医学
癌症
免疫学
内科学
细胞生物学
放射治疗
生物技术
作者
Zhi Wang,Tao Zhou,Xubo Chen,Xiaofan Zhu,Yiji Liao,Jianguo Liu,Siqi Li,Ting Tan,Yuehui Liu
出处
期刊:Neoplasma
[AEPress, s.r.o.]
日期:2024-01-01
卷期号:70 (06): 761-776
标识
DOI:10.4149/neo_2023_221021n1039
摘要
Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck. A number of studies have confirmed that coiled-coil domain-containing protein 86 (CCDC86) plays an important role in the pathogenesis of lymphoma but the role of CCDC86 in NPC has not yet been reported. Here, in vivo and in vitro experiments were conducted to explore whether CCDC86 plays a role in the pathogenesis of NPC and to identify the specific mechanism. We found that CCDC86 was highly expressed in NPC tissues and cells, and the expression level of CCDC86 was correlated with the prognosis of patients with advanced NPC. CCDC86 promoted the proliferation, invasion, and migration of NPC cells in vivo and in vitro by promoting the EMT process and upregulating the expression of MMPs. Then, we confirmed that EGFR is a downstream target gene of CCDC86 and that CCDC86 can promote the proliferation, invasion, and migration of NPC cells by upregulating the expression of EGFR and activating downstream PI3K/Akt. Furthermore, we confirmed that CCDC86 did not directly bind to EGFR but positively regulated EGFR by binding to NPM1. CCDC86 is expected to be used as a novel biomarker and therapeutic target for predicting the prognosis of NPC.
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