Photo‐Induced Synthesis of Functionalized γ‐Lactams via Iron‐Catalyzed LMCT Cascade

Abstract A base‐and‐additive‐free photo‐induced radical‐mediated cascade cyclization reaction of 1,6‐enyne compounds was presented. In this study, C( sp 3 )−H hydrocarbons, including various alkanes and ethers, were activated via Fe‐catalyzed photo‐induced conditions, providing a bunch of γ‐lactam products via hydrogen atom transfer and radical addition processes. Control experiments indicated that the reaction proceeded through photo‐induced ligand‐to‐metal charge transfer (LMCT) process. Gram scale experiment was also completed by using continuous‐flow‐photocatalytic‐device.