环糊精
脂质体
抗氧化剂
化学
药品
纳米-
柠檬烯
制药技术
毒品携带者
药物输送
药理学
纳米技术
色谱法
化学工程
有机化学
材料科学
医学
生物化学
工程类
精油
作者
Jian Huang,Z Fang,Bai Chun,Yulin Mo,Dingkun Liu,Bing Yang,Xiaobin Jia,Liang Feng
标识
DOI:10.1016/j.ijpharm.2024.123914
摘要
Drug-in-cyclodextrin-in-liposome (DCL) combines advantages of cyclodextrin and liposome. Here, DCL formulation was successfully prepared to encapsulate limonene (Lim), whose characterization revealed that particle size was 147.5±1.3 nm and zeta potential was -48.7±0.8 mV. And the complexation mechanism of Lim/HP-β-CD inclusion complex (the intermediate of DCL) was analyzed by molecular dynamics simulation, showing that Lim was entrapped into the cavity of HP-β-CD through electrostatic and hydrophobic interaction with a molar ratio of 1:1. Notably, DCL formulation not only reduced Lim volatilization in 25℃, but also enhanced the free radical (DPPH· and ABTS·+) scavenging ability of Lim. In summary, Lim-DCL formulation improved the stability and enhanced the antioxidant activity of Lim. DCL nanocarrier system is suitable to preserve volatile and hydrophobic compounds, enlarging their application in pharmaceutics industries.
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