丝素
材料科学
膜
蜘蛛丝
组织工程
丝绸
微型多孔材料
脚手架
纳米技术
生物医学工程
复合材料
工程类
化学
生物化学
作者
Wenze Chen,Keyin Liu,Xiaoyü Li,Jinglei Wu,Chen Lü,Zihan Yang,Xiping Wang,Yun Liao,Guohua Fu,Xubo Yang,Zhen Wang,Guanlin Qu,Luyao Wang,Yuqiong Zhou,Zhiyuan Zhang,Yang Chen,Shibing Ni,Jun Zheng,Tiger H. Tao,Duohong Zou
标识
DOI:10.1002/adma.202310697
摘要
Guided bone regeneration gathers significant interest in the realm of bone tissue engineering; however, the interplay between membrane thickness and permeability continues to pose a challenge that can be addressed by the water-collecting mechanism of spider silk, where water droplets efficiently move from smooth filaments to rough conical nodules. Inspired by the natural design of spider silk, an innovative silk fibroin membrane is developed featuring directional fluid transportation via harmoniously integrating a smooth, dense layer with a rough, loose layer; conical microchannels are engineered in the smooth and compact layer. Consequently, double-layered membranes with cone-shaped microporous passageways (CSMP-DSF membrane) are designed for in situ bone repair. Through extensive in vitro testing, it is noted that the CSMP-DSF membrane guides liquid flow from the compact layer's surface to the loose layer, enabling rapid diffusion. Remarkably, the CSMP-DSF membrane demonstrates superior mechanical properties and resistance to bacterial adhesion. When applied in vivo, the CSMP-DSF membrane achieves results on par with the commercial Bio-Gide collagen membranes. This innovative integration of a cross-thickness wetting gradient structure offers a novel solution, harmonizing the often-conflicting requirements of material transport, mechanical strength, and barrier effectiveness, while also addressing issues related to tissue engineering scaffold perfusion.
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