化学
四级碳
碳纤维
联轴节(管道)
第四纪
催化作用
立体化学
有机化学
机械工程
古生物学
材料科学
复合数
工程类
复合材料
生物
对映选择合成
作者
Qiao Zhang,Xiangyu Liu,Yandong Zhang,Mengying Huang,Xinyu Zhang,Shou‐Fei Zhu
摘要
The construction of quaternary carbon centers via C–C coupling protocols remains challenging. The coupling of tertiary C(sp3) with secondary or tertiary C(sp3) counterparts has been hindered by pronounced steric clashes and many side reactions. Herein, we have successfully developed a type of bisphosphine ligand iron complex-catalyzed coupling reactions of tertiary alkyl halides with secondary alkyl zinc reagents and efficiently realized the coupling reaction between tertiary C(sp3) and secondary C(sp3) with high selectivity for the initial instance, which provided an efficient method for the construction of quaternary carbon centers with high steric hindrance. The combination of an iron catalyst and directing group of the substrate makes the great challenging transformation possible.
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