六烯酸
发酵
食品科学
生产(经济)
化学
生物
生物技术
生物化学
脂肪酸
多不饱和脂肪酸
经济
宏观经济学
作者
Liucheng Long,Ren Xiao-qing,Shouxin Zhang,Aijia Shi,Yida Zhai,Wuxi Chen,Yu Duan,Pengbao Shi,Limei Chen,Demao Li
出处
期刊:Fermentation
[Multidisciplinary Digital Publishing Institute]
日期:2024-09-04
卷期号:10 (9): 460-460
标识
DOI:10.3390/fermentation10090460
摘要
There is significant demand for high-purity DHA in the pharmaceutical industry. Traditionally, this high-purity DHA is extracted from raw materials with relatively low DHA content (10–20%), such as fish oil. Recently, through electroporation-induced mutation, a high-DHA-content strain of Schizochytrium sp. GCD2032 was isolated. To further enhance its DHA production, optimizations were conducted on the culture medium and fermentation conditions (in shaking flasks), as well as different nitrogen source concentrations (in a 5 L fermenter) for biomass, fatty acid content, and DHA content (as a percentage of total fatty acids). In a 5 L fermenter, Schizochytrium sp. GCD2032 achieved a biomass of 50 g/L, with fatty acid content of 55.71% and DHA content of 61.29%. Notably, the DHA content reached an impressive 341.45 mg/g of dry weight. This strain consistently produces high levels of fatty acids and DHA, demonstrating significant potential for pharmaceutical applications.
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