机制(生物学)
PARP抑制剂
聚ADP核糖聚合酶
抗性(生态学)
化学
计算生物学
遗传学
生物
DNA
哲学
聚合酶
认识论
生态学
作者
Yi Huang,Simin Chen,Nan Yao,Shikai Lin,Junyi Zhang,Chengrui Xu,Chenxuan Wu,Guo Chen,Danyang Zhou
出处
期刊:Oncoscience
[Impact Journals LLC]
日期:2024-09-23
卷期号:11: 69-91
标识
DOI:10.18632/oncoscience.610
摘要
Poly (ADP-ribose) polymerases (PARP) inhibitors (PARPi) are the first-approved anticancer drug designed to exploit synthetic lethality. PARPi selectively kill cancer cells with homologous recombination repair deficiency (HRD), as a result, PARPi are widely employed to treated
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