钆
磁共振成像
化学
体内
共价键
核磁共振
冲刷
生物物理学
赫拉
临床前影像学
材料科学
碱性磷酸酶
离体
肿瘤进展
生物医学工程
癌症研究
作者
Zheng Huang,Yinxing Miao,Chunmei Lu,Jie-wei Luo,Yan Zhang,Deju Ye
标识
DOI:10.1002/anie.202516998
摘要
(0.5 T, 21.3 MHz, 32 °C) and effectively "traps" the probe at the tumor site. P-QM-Gd showed rapid tumor uptake and efficient covalent labeling, achieving distinct MR contrast enhancement (> 60%). The imaging window was extended for up to 24 h in subcutaneous HeLa and orthotopic K7M2 tumor models. Notably, delayed MRI with P-QM-Gd enabled precision visualization of ∼1.3 mm orthotopic K7M2 tumors in mice. By overcoming the rapid washout and low sensitivity inherent to traditional small-molecule MRI probes through this enzymatic self-immobilization strategy, P-QM-Gd offers a promising approach for high-sensitivity, high-spatial resolution delayed tumor MRI, making it particularly effective for early-stage lesion detection.
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