Sugar Rationing in the First 1000 Days After Conception and Long-term Risk of Metabolic Dysfunction-associated Steatotic Liver Disease and Major Adverse Liver Outcomes: A Natural Experiment Study

Early-life sugar restriction during critical developmental windows is associated with lower adult risk of MASLD and liver complications, primarily mediated by improved metabolic profiles. Policy efforts targeting sugar intake in pregnancy and early childhood may provide durable benefits for liver and metabolic health.