氢胺化
苯并咪唑
化学
咪唑
炔烃
组合化学
吡嗪
分子内力
乌吉反应
异氰
苯氮卓类
甲醇
有机化学
催化作用
作者
Behnam Tahmasebi,Mehdi Adib,Mohammad Mahdavi,Parham Taslimi
标识
DOI:10.1002/slct.202301475
摘要
Abstract This study reported an efficient two‐step method based on the sequential post‐Ugi hydroamination reaction for synthesizing a novel class of benzimidazole‐pyrazines with high yields. First, a Ugi fourcomponent reaction (Ugi‐4CR) is carried out using readily available starting materials, i. e., 1 H ‐benzo[d]imidazole‐2‐carboxylic acid, aldehydes, propargylamine, and isocyanides, in methanol at ambient temperature. Afterward, the Ugi products undergoes a sequential intramolecular hydroamination/cyclization reaction between a nitrogen of imidazole and alkyne functional group in aqua media in the presence of AuCl 3 as a catalyst to obtain benzimidazole‐pyrazine products. These heterocyclic compounds may have a potential to be utilized in designing modern drugs with desirable features.
科研通智能强力驱动
Strongly Powered by AbleSci AI