医学
独生子女
产科
怀孕
随机对照试验
早产
宫颈环扎术
早产
经阴道超声
妇科
胎儿
妊娠期
超声波
外科
遗传学
放射科
生物
作者
Vincenzo Berghella,Moti Gulersen,Amanda Roman,Rupsa C. Boelig
标识
DOI:10.1016/j.ajogmf.2023.101116
摘要
After the United States Food and Drug Administration pulled 17-alpha hydroxyprogesterone caproate from the market for its use in prevention of recurrent spontaneous preterm birth, national societies have had mixed recommendations regarding the management of patients with a singleton pregnancy and previous spontaneous preterm birth. Herein we highlight the randomized trial data and translational evidence supporting the use of vaginal progesterone for prevention of recurrent spontaneous preterm birth in singleton pregnancies. Prophylactic vaginal progesterone starting at 16 weeks and 0 days every night should be offered to patients with singletons and previous singleton spontaneous preterm birth regardless of cervical length, and continued along with placement of cerclage if a transvaginal ultrasound cervical length ≤25 mm is detected at <24 weeks.
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