索马里风
聚乙烯醇
纳米纤维
他达拉非
纳米颗粒
材料科学
传统医学
生物医学工程
化学
复合材料
纳米技术
医学
外科
勃起功能障碍
替代医学
病理
作者
Asmaa M Elsherbini,Sally Sabra,Shimaa Anwar Rashed,Doaa A. Abdelmonsif,Medhat Haroun,Thanaa I. Shalaby
出处
期刊:Nanomedicine
日期:2023-08-01
卷期号:18 (20): 1361-1382
被引量:1
标识
DOI:10.2217/nnm-2023-0127
摘要
Background: Impaired inflammation and vascularization are common reasons for delayed diabetic wound healing. Nanoparticles (NPs)-in-nanofibers composites can manage diabetic wounds. A multifunctional scaffold was developed based on tadalafil (TDF)-loaded NPs incorporated into polyvinyl alcohol/Withania somnifera extract nanofibers. Materials & methods: TDF-loaded NPs were prepared and fully characterized in terms of their physicochemical properties. Extract of ashwagandha was prepared and a blend composed of TDF-loaded NPs, herbal extract and polyvinyl alcohol was used to prepare the whole composite. Results: The whole composite exhibited improved wound closure in a diabetic rat model in terms of reduced inflammation and enhanced angiogenesis. Conclusion: Results suggest that this multifunctional composite could serve as a promising diabetic wound dressing.
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