生物
RNA聚合酶Ⅱ
核糖核酸
抄写(语言学)
基因表达
遗传学
过程性
延伸率
细胞生物学
基因
基因表达调控
聚合酶
发起人
语言学
哲学
材料科学
极限抗拉强度
冶金
作者
Yuki Aoi,Ali Shilatifard
出处
期刊:Molecular Cell
[Elsevier]
日期:2023-11-01
卷期号:83 (22): 3972-3999
被引量:9
标识
DOI:10.1016/j.molcel.2023.10.004
摘要
The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the regulation of gene expression in response to developmental and environmental cues in metazoan. Dysregulated transcriptional elongation has been associated with developmental defects as well as disease and aging processes. Decades of genetic and biochemical studies have painstakingly identified and characterized an ensemble of factors that regulate RNA Pol II elongation. This review summarizes recent findings taking advantage of genetic engineering techniques that probe functions of elongation factors in vivo. We propose a revised model of elongation control in this accelerating field by reconciling contradictory results from the earlier biochemical evidence and the recent in vivo studies. We discuss how elongation factors regulate promoter-proximal RNA Pol II pause release, transcriptional elongation rate and processivity, RNA Pol II stability and RNA processing, and how perturbation of these processes is associated with developmental disorders, neurodegenerative disease, cancer, and aging.
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