电泳剂
试剂
化学
部分
亲核细胞
电子转移
药物化学
组合化学
立体化学
有机化学
催化作用
作者
Ze-Yuan Ma,Mao Xiao,Chengkun Li,Adedamola Shoberu,Jian‐Ping Zou
标识
DOI:10.1016/j.cclet.2023.109076
摘要
An efficient synthesis of the electrophilic reagent, S-(1,3-dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate (SDDP) is described. Moreover, the synthetic applications of SDDP wherein the transfer of the SP(O)(OEt)2 moiety occurs were investigated. In this manner, SDDP underwent facile SP(O)(OEt)2 transfer with electron-rich substrates such as ketones, indoles, and thiols to form α-phosphorothiolated ketones, 3-phosphorothiolated indoles and S-phosphorothiolated thioethers, respectively.
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