Синтез эритропоэтина почками у больных сахарным диабетом 1-го типа с анемией

Goal: to examine the level of erythropoietin among patients with diabetes mellitus type 1 (DM 1) and different types of anemia and stages of diabetic nephropathy. Materials and methods: erythropoietin level analysis were conducted among 121 patients with DM 1 with and without anemia. Results: patients suffering from DM type 1 with anemia for less than 5 years have higher erythropoietin rates, than those who have DM for 5-15 years and longer time. Patients who suffer from DM for more than 15 years have the same erythropoietin rates regardless of the fact if they also have anemia or not. DM patients with anemia experience the decrease of erythropoietin level as far as Chronic Kidney Disease (CKD) is progressing. This decrease becomes statistically significant among patients with CKD of the 3, 4, and 5 stages (in comparison with patients without diabetic nephropathy (p=0,00)). Patients with Anemia Chronic Disease (ACD) and CKD have the same erythropoietin rates as patients without anemia (p=0,93 and p=0,40). Conclusion: The longer patients suffer from DM 1 and the CKD progress, the more the level of erythropoietin is going down. At duration DM 1 more than 15 years level of erythropoietin at patients DM with anemia corresponds to level of erythropoietin at patients without anemia. Patients with ACD don't have correlation of level of hemoglobin with erythropoietin. Where there is ACD, no hemoglobin-related increase in erythropoietin level is observed (which can be the reason of its appearance and advance). Patients with iron deficiency anemia, have elevating the level of erythropoietin despite an appreciable lesion of function of kidneys.