ISOXAZOLES: MOLECULES WITH POTENTIAL MEDICINAL PROPERTIES

Isoxazole is a five membered heterocyclic compd. having various pharmacol. actions. The great interest assocd. with isoxazoles and their derivs. is based on their versatility as synthetic building blocks, their latent functionalities as enaminones, 1,3-dicarbonyl compds., γ-amino alcs. and β-hydroxy nitriles have been widely exploited for the synthesis of other heterocycles and complex mols. This review paper comprises of up to date information on isoxazole analogs. More emphasis was given to crit. discussion on the synthetic strategy of isoxazole deriv., their utility as building blocks in their transformation to more biol. potent mols. Results of isoxazole derivs. and their substitutions effect on diverse biol. activities are also presented. [on SciFinder(R)]