Neuroimaging Biomarkers in Schizophrenia

AbstractSchizophrenia is a highly heritable and devastating mental disorder with a complex genetic architecture. The combination of multimodal neuroimaging with genetic mapping techniques and the subsequent assessment of genomic variation (“imaging genetics”) has recently proved to be exceptionally powerful in advancing our understanding of the neural underpinnings of normal cognition and mental disease states. This upcoming research field has opened doors to a previously inaccessible level of both biological characterization and the validation of schizophrenia risk gene effects. This chapter reviews the current scientific knowledge on neuroimaging biomarkers in schizophrenia and illustrates the major conceptual change in the way in which biological intermediate phenotypes are viewed and pursued in psychiatry today.KeywordsDiffusion Tensor ImagingAtypical AntipsychoticSchizophrenia PatientGray Matter VolumeWork Memory LoadThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.