Effect Evaluation of Forest Fire on Governor Station

PM_2.5 pollution was associated with numerous adverse health effects. However, PM_2.5 induced toxic effects and the relationships with toxic components remain largely unknown. To evaluate the metabolic toxicity of PM_2.5 at environmentally relevant doses, investigate the seasonal variation of PM_2.5 induced toxicity and the relationship with toxic components, a combination of general pathophysiological tests and metabolomics analysis was conducted in this study to explore the response of SD rats to PM_2.5 exposure. The result of general toxicology analysis revealed unconspicuous toxicity of PM_2.5 under environmental dose, but winter PM_2.5 at high dose caused severe histopathological damage to lung. Metabolomic analysis highlighted significant metabolic disorder induced by PM_2.5 even at environmentally relevant doses. Lipid metabolism and GSH metabolism were primarily influenced by PM_2.5 exposure due to the high levels of heavy metals. In addition, high levels of organic compounds such as PAHs, PCBs and PCDD/Fs in winter PM_2.5 bring multiple overlaps on the toxic pathways, resulting in larger pulmonary toxicity and metabolic toxicity in rats than summer.