兰索拉唑
TBARS公司
髓过氧化物酶
硫代巴比妥酸
肠粘膜
化学
药理学
脂质过氧化
肠系膜上动脉
血红蛋白
小肠
炎症
医学
氧化应激
内分泌学
内科学
生物化学
奥美拉唑
作者
Hiroshi Ichikawa,Norimasa Yoshida,Tomohisa Takagi,Naoya Tomatsuri,Kazuhiro Katada,Yutaka Isozaki,Kazuhiko Uchiyama,Yuji Naito,Takeshi Okanoue,Toshikazu Yoshikawa
标识
DOI:10.3748/wjg.v10.i19.2814
摘要
To investigate the protective effect of lansoprazole on ischemia and reperfusion (I/R)-induced rat intestinal mucosal injury in vivo.Intestinal damage was induced by clamping both the superior mesenteric artery and the celiac trunk for 30 min followed by reperfusion in male Sprague-Dawley rats. Lansoprazole was given to rats intraperitoneally 1 h before vascular clamping.Both the intraluminal hemoglobin and protein levels, as indices of mucosal damage, significantly increased in I/R-groups comparison with those of sham-operation groups. These increases in intraluminal hemoglobin and protein levels were significantly inhibited by the treatment with lansoprazole at a dose of 1 mg/kg. Small intestine exposed to I/R resulted in mucosal inflammation that was characterized by significant increases in thiobarbituric acid-reactive substances (TBARS), tissue-associated myeloperoxidase activity (MPO), and mucosal content of rat cytokine-induced neutrophil chemoattractant-1 (CINC-1). These increases in TBARS, MPO activities and CINC-1 content in the intestinal mucosa after I/R were all inhibited by pretreatment with lansoprazole at a dose of 1 mg/kg. Furthermore, the CINC-1 mRNA expression was increased during intestinal I/R, and this increase in mRNA expression was inhibited by treatment with lansoprazole.Lansoprazole inhibits lipid peroxidation and reduces development of intestinal mucosal inflammation induced by I/R in rats, suggesting that lansoprazole may have a therapeutic potential for I/R injury.
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