间质细胞
伤口愈合
角膜
炎症
免疫系统
肌成纤维细胞
有丝分裂
细胞生物学
医学
基质
角膜上皮
上皮
病理
生物
癌症研究
免疫学
纤维化
眼科
免疫组织化学
作者
Steven E. Wilson,R R Mohan,R R Mohan,Renato Ambrósio,Jinsheng Hong,Jae Woo Lee
标识
DOI:10.1016/s1350-9462(01)00008-8
摘要
The corneal wound healing cascade is complex and involves stromal–epithelial and stromal–epithelial–immune interactions mediated by cytokines. Interleukin-1 appears to be a master modulator of many of the events involved in this cascade. Keratocyte apoptosis is the earliest stromal event noted following epithelial injury and remains a likely target for modulation of the overall wound healing response. Other processes such as epithelial mitosis and migration, stromal cell necrosis, keratocyte proliferation, myofibroblast generation, collagen deposition, and inflammatory cell infiltration contribute to the wound healing cascade and are also likely modulated by cytokines derived from corneal cells, the lacrimal gland, and possibly immune cells. Many questions remain regarding the origin and fate of different cell types that contribute to stromal wound healing. Over a period of months to years the cornea returns to a state similar to that found in the unwounded normal cornea.
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