幽门螺杆菌
端粒酶
端粒
甲硝唑
克拉霉素
胃肠病学
阿莫西林
内科学
胃粘膜
癌症
活检
胃窦
胃炎
医学
生物
抗生素
微生物学
胃
基因
遗传学
作者
Rahmi Aslan,Ahmet Bektaş,Abdülkerim Bedir,Hasan Alaçam,Melek Süzer Aslan,Rukiye Nar,Beytullah Yıldırım,İbrahim Gören,Özgür Ecemiş,Müge Ustaoğlu,Fikret Gören,Ali Okuyucu
出处
期刊:PubMed
日期:2013-05-01
卷期号:60 (123): 601-4
被引量:10
摘要
Our purpose in this study was to analyze telomere length and telomerase activity before and after eradication treatment in gastric mucosa in patients positive for H. pylori.There were two groups: a control group (n=17) and a study group (n=21). For H. pylori eradication, the patients were administrated proton pump inhibitor (PPI) + clarithromycin + amoxicillin or PPI + metronidazole + tetracycline + bismuth for 14 days. Telomere length was analyzed with RT-PCR and telomerase activity with PCR-ELISA on biopsy specimens from the antrum. The result p<0.05 was considered significant.Prior to eradication, there was no significant difference between telomere lengths of the patient and control groups (2481.2±1823 and 2958.9±1345.7 bp, p=0.11, respectively). The telomere length of the study group became longer after eradication (before 2481.2±1823bp, after 3766.3±1608.8bp, p=0.01). Telomerase activity was not detected in either the patient or the control group.An increase in telomere length was observed with H. pylori eradication. This finding may indicate the importance of H. pylori eradication to avoid the development of gastric cancer.
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