Comparison of Histological Quality Between 22-Gauge Fine Needle Aspiration and Fine Needle Biopsy of Solid Pancreatic Lesions

Aims Regarding pancreatic lesions, most studies comparing EUS-FNA (endoscopic ultrasound guided fine needle aspiration) and EUS-FNB (fine needle biopsy) have shown no difference in term of diagnostic accuracy. Few studies have assessed the quality of histological samples obtained with each needles. The aim of the present study was to compare the histological quality of samples obtained with EUS-FNA and EUS-FNB for pancreatic solid lesion. Methods We performed a retrospective study in a single tertiary center including all consecutive patients who underwent EUS-guided sampling procedure of a pancreatic lesion from January 2017 to October 2018, with either a 22G FNA needle or a 22G FNB needle. For each sample, cellularity was determined and all core tissues were manually delineated for area measurement. Results Eighty-eight patients were included. Among them 40 (45.5 %) underwent EUS-FNA and 48 (54.5 %) underwent EUS-FNB. A core tissue was obtained in 15/40 (37.5 %) of the cases in the EUS-FNA group versus 42/48 (87.5 %) in the EUS-FNB group (p < 0.005). The mean area of the total core tissue obtained was 0.4 +/- 0.7 mm 2 the EUS-FNA group and 2.8 +/- 3.3 mm 2 in the EUS-FNB group (p=0.005). EUS-FNA samples had a mean cellularity of 40740.4 cells +/- 73243.0 versus 25987.8+/- 45861.7 for EUS-FNB samples without statistical significance (p= 0.3). In the EUS-FNA group, 4 (10.0 %) cases of immediate minor hemorrhages were observed. No adverse event was observed within 30 days after the endoscopic procedure. In the EUS FNB group, no adverse event was observed during the procedure or within 30 days after the endoscopic procedure. Conclusions FNB allowed to obtain a core tissue in near 90 % of the cases and the mean area of the core tissues obtained was 7-fold bigger than those obtained with FNA. FNB should be the needle of choice to obtain a large amount of pancreatic tissue. Citation Lambin T , Karleskind O, Leteurtre E et al. eP383 COMPARISON OF HISTOLOGICAL QUALITY BETWEEN 22-GAUGE FINE NEEDLE ASPIRATION AND FINE NEEDLE BIOPSY OF SOLID PANCREATIC LESIONS. Endoscopy 2021; 53: S221. Publication History Publication Date: 19 March 2021 (online) © 2021. European Society of Gastrointestinal Endoscopy. All rights reserved. Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany